Fig 10. Ultrastructural analysis of the vps24 mutant.

Transmission electron microscopy images of CNS neurons (A) and DLM (B) from WT (a) or the vps24 mutant (b). The vps24 mutant exhibited accumulation of autolysosomes (arrows) and tubular membrane compartments (double arrows) as well as autophagosome structures (filled arrowheads), whereas these were absent in WT. The electron dense tubular membrane compartment appeared to be continuous with some electron dense spherical autolysosomes (open arrowheads). In mutant muscle, mitochondria appear to be swollen. Double arrowheads, autophagic intermediates closely associated with spherical autolysosome structures (see S10 Fig); M, mitochondrion.