Table 1. Vaccine trials for WNV.
| VACCINES | ||||||||
|---|---|---|---|---|---|---|---|---|
| Title | NCT Number | Dates | Phase | Status | Interventions | Number Enrolled | Sponsor/ Collaborators | Publications |
| Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4-3’delta30) in Healthy Adults | NCT00094718 | Posted: 10/22/2004 Completed: 4/2005 | 1 | Completed | WN/DEN4-3’delta30 vs Placebo (vaccine diluent) | 56 | Johns Hopkins Bloomberg School of Public Health, NIAID* | PMID: 23968769 |
| Safety of and Immune Response to a West Nile Virus Vaccine (WN/DEN4delta30) in Healthy Adults | NCT00537147 | Posted: 9/28/2007 Completed: 6/2009 | 1 | Completed | WN/DEN4delta30 vs Placebo (vaccine diluent) | 26 | Johns Hopkins Bloomberg School of Public Health, NIAID* | |
| Evaluating the Safety and Immunogenicity of a Live Attenuated West Nile Virus Vaccine for West Nile Encephalitis in Adults 50 to 65 Years of Age | NCT02186626 | Posted: 7/10/2014 Completed: 7/2016 | 1 | Completed | WN/DEN4delta30 vs Placebo (vaccine diluent) | 28 | NIAID* | PMID: 28077583 |
| Vaccine to Prevent West Nile Virus Disease | NCT00106769 | Posted: 3/30/2005Completed: 1/15/2008 | 1 | Completed | VRC-WNVDNA017-00-VP | 15 | National Institutes of Health Clinical Center, NIAID* | PMID: 18190252 |
| Phase I Study of West Nile Virus Vaccine | NCT00300417 | Posted: 3/8/2006 Completed: 12/28/2007 | 1 | Completed | VRC-WNVDNA020-00-VP | 30 | National Institutes of Health Clinical Center, NIAID* | PMID: 21398392 |
| Safety and Immunogenicity of ChimeriVax-WN02 West Nile Vaccine in Healthy Adults | NCT00442169 | Posted: 3/1/2007 Completed: 4/2009 | 2 | Completed | ChimeriVax-WN02 vs Placebo (normal saline) | 208 | Sanofi Pasteur | PMID: 21148499 |
| Safety and Immunogenicity Study of ChimeriVax West Nile Vaccine in Healthy Adults | NCT00746798 | Posted: 9/4/2008 Completed: 12/2009 | 2 | Completed | ChimeriVax-WN02 vs Placebo (normal saline) | 479 | Sanofi Pasteur | PMID: 22959989 |
| Safety Study of HBV-002 West Nile Vaccine in Healthy Adults | NCT00707642 | Posted: 7/1/2008 Completed: 6/2009 | 1 | Completed | WN-80E | 25 | Hawaii Biotech, Inc | Patent listing: http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=10039820.PN.&OS=PN/10039820&RS=PN/10039820 |
| Phase 1 Trial of Inactivated West Nile Virus Vaccine | NCT02337868 | Posted: 1/14/2015 Completed: 12/16/2016 | 1 | Completed | HydroVax-001 vs Placebo | 96 | NIAID* | PMID: 30661836 |
*NIAID, National Institute of Allergy and Infectious Diseases.
WNV, West Nile virus.