Fig 10. Co-colonization of E. coli^Bt suppresses P. aeruginosa-mediated enhancement of polyQ aggregation.

A) The effect of butyrogenic bacteria (E. coli^Bt) on the aggregation of intestinal polyQ44 (AM738) in worms co-colonized with E. coli OP50 or P. aeruginosa in the presence and absence of 3% L-arabinose. Data are represented as the average number of aggregates per intestine. Each bar is an average of three independent experiments with a total of 100 animals. Error bars represent SEM. Statistical significance between each pair was calculated using Student’s t-test (****p<0.0001). B) Model figure. Enteropathogenic bacteria disrupt proteostasis across C. elegans tissues, including intestine, muscle, neurons, and gonads. The bacteria-mediated proteotoxicity is alleviated by butyrate and butyrogenic bacteria.