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. 2021 May 6;16(5):e0250431. doi: 10.1371/journal.pone.0250431

Table 3. Patterns of change from pre-treatment to 3 month follow-up*, according to percent volume of activation; wrist extension motor task.

PATTERN OF CHANGE
I. Brain Region II. Decrease Change in % Volume of Activation (Subject number) III Increase Change in % Volume of Activation (Subject number) IV. No Change in % Volume of Activation (Subject number)
A. lesioned hemisphere, contralateral to the moving wrist)
1. Primary Motor (BA 4ap)
 1.1. ‘Hand Knob’ sub-section of Primary Motor 03% (S1) 48% (S2) 20% (S3) (S4)**
 1.2. Primary Motor sub-section, minus ‘Hand knob’ 19% (S1) 24% (S2) 3% (S3) (S4)
2. Premotor (BA 6) 13% (S1) 26% (S2) 02% (S4) 6% (S3)
3. Sensory (BA 3ab) 28% (S1) 20% (S2) 01% (S3) 26% (S4)
B. Ipsilateral (non-lesioned; right)
1. Primary Motor (BA 4ap)
 1.1. ‘Hand Knob’ sub-section of Primary Motor 30% (S1) 68% (S2) 20% (S3) 03% (S4)
 1.2. Primary Motor sub-section minus ‘Hand knob’ 26% (S1) 40% (S2) 19% (S4) (S3)
2. Premotor (BA 6) 13% (S1) 25% (S2) 19% (S4) 03% (S3)
3. Sensory (BA 3ab) 11% (S1) 10% (S4) (S2) (S3)

Key: S: Subject.

* Change values for S4 were calculated using pre-treatment and post-treatment because the follow-up values for S4 were zero’s, which could spuriously increase the change values; this situation of zero’s at follow-up could have arisen due to his expressed discouragement at having had no treatment between post-treatment and follow-up and an obvious worsening of motor control.

**No Hand Knob region could be identified in the surviving tissue of S4’s lesioned hemisphere.