SARS-CoV-2 induces specific phenotype of circulating immune cells
CellCnn analysis performed on single cells from myeloid (top) and lymphoid (bottom) panels on 39 samples at admission (day 0) (COVID-19− [n = 9] and COVID-19+ [n = 30])
(A) Frequencies of cells discovered by the best-performing CellCnn filter in COVID-19− (blue) and COVID-19+ (orange) patients for each panel. Mann-Whitney tests, ∗∗∗∗p < 0.0001.
(B) Cells defined by the best-performing CellCnn filters enrichment shown on tSNE and representative markers for each panel (CD14 and CD38 [see additional markers in Figure S2]).