Table II.
Target Organ Abnormalities
| Entire Cohort | Not On Medication at Baseline | On Medication at Baseline: Not Controlled | On Medication at Baseline: Controlled | |
|---|---|---|---|---|
| Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | |
| Left ventricular hypertrophy (n=278 for echo; n=301 for ECG) | ||||
| Echo LVM (g) | 211 (68) | 210 (67) | 223 (73) | 192 (58) |
| Echo LVM/ht2.7 | 45.9 (14.6) | 45.3 (13.7) | 48.0 (15.2) | 43.6 (15.4) |
| Echo LVM/BSA | 108 (35) | 108 (35) | 112 (36) | 100 (31) |
| Echo LVH % (LVM/ht2.7) | 30% | 29% | 37% | 21% |
| Echo LVH % (LVM/BSA) | 25% | 26% | 30% | 14% |
| ECG sum Cornell voltage | 18.4 (9.0) | 18.0 (8.3) | 20.2 (9.1) | 15.7 (9.7) |
| ECG LVH Cornell voltage % | 12% | 11% | 18% | 4% |
| ECG strain pattern | 3% | 4% | 5% | 0 |
| Nonspecific T wave abnormality | ||||
| Major | 15% | 16% | 17% | 9% |
| Minor | 18% | 13% | 26% | 16% |
| Diastolic function (n=284) | ||||
| E wave velocity (cm/sec) | 69 (16) | 69 (14) | 68 (17) | 70 (16) |
| A wave velocity (cm/sec) | 64 (13) | 62 (13) | 65 (14) | 65 (12) |
| E/A wave ratio | 1.1 (0.3) | 1.15 (0.33) | 1.08 (0.29) | 1.10 (0.30) |
| Deceleration time (msec) | 202 (68) | 198 (68) | 202 (71) | 211 (62) |
| E/A ratio <1.0 | 38% | 33% | 45% | 39% |
| Deceleration time >240 msec | 25% | 21% | 27% | 29% |
| Systolic function (n=248) | ||||
| Ejection fraction | 69 (13) | 68 (13) | 68 (14) | 71 (8) |
| Ejection fraction <50% | 7% | 8% | 10% | 0% |
| Renal function (n=298 for serum; n=281 for urine) | ||||
| Serum creatinine (mg/dL) | 1.3 (0.9) | 1.2 (0.8) | 1.4 (0.9) | 1.3 (1.0) |
| Creatinine >1.6 (mg/dL) | 10% | 7% | 14% | 11% |
| Urine Cr Cl (mL/min/1.73 m2) | 102 (37) | 102 (34) | 103 (42) | 99 (32) |
| Cr Cl <60 (mL/min/1.73 m2) | 9% | 7% | 10% | 11% |
| Urine albumin/creatinine ratio | 187 (569) | 125 (451) | 262 (697) | 210 (571) |
| Microalbuminuria (%) | 21% | 21% | 24% | 15% |
| Gross proteinuria (%) | 13% | 8% | 20% | 13% |
| Proteinuria (%) | 34% | 29% | 42% | 28% |
| echo=echocardiography; LVM=left ventricular mass; ECG=electrocardiography; BSA=body surface area; LVH=left ventricular hypertrophy; Cr Cl=creatinine clearance | ||||