| Precipitant Drug
|
Effect
|
Description
|
| Beta blockers (atenol, propanol) |
— |
Caffeine effect is similar with and without β blockers. Caffeine reduces the antihypertensive effect of these drugs |
| Cimetidine (Tagamet®, Zantac®) |
↑ |
Caffeine hepatic metabolism may be impaired, increasing caffeine |
| Disulfiram (Antabuse®) |
↑ |
|
| Fluoroquinolones (Cipro®, norfloxacin) |
half‐life and caffeine effect |
|
| Terbinafine (Lamisil®) |
↑ |
|
| Contraceptives, oral (Ortho‐Cyclen®, Alesse™, Triphasil®) |
↑ |
|
| Mexiletine (Mexitil®) |
↑ |
Caffeine elimination may be reduced 30%–50% (effect may be greater) |
| Phenylpropanolamine (Accutrim®, Dexatrim®) |
↑ |
Serum caffeine levels may be increased Caffeine effects are enhanced |
