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Administration of 1 mg losartan (representing 1/30th of the dose producing a 10% decrease in blood pressure) in an experimental model of penile erection produced an immediate increase in intracavernosal pressure, followed by multiple waves of increased pressure. The increase in intracavernosal pressure was significantly correlated with losartan dose (p<0.001). Data derived from J Urol. 1997;157(5):.1920–1925. 13
