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. 2021 May 6;140:111685. doi: 10.1016/j.biopha.2021.111685

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Fig. 2 — ACE2 as a key contributor to SARS-CoV-2 infection in metabolic organs. ACE2 is widely expressed in metabolic organs including liver, pancreas, heart, and gut. SARS-CoV-2 infection evokes notable downregulation of ACE2 and consequent imbalance of ACE/ACE2, thereby causing virus-induced damage and dysfunction in metabolic organs and consequent worsen metabolic complications in patients with COVID-19. SARS-CoV-2, syndrome coronavirus 2; ACE, angiotensin-converting enzyme; ACE2, angiotensin-converting enzyme 2.