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. 2021 May 6;2(5):e250–e262. doi: 10.1016/S2666-7568(21)00062-3

Figure 3.

Figure 3

Change in interferon-induced antiviral gene expression from baseline to week 16 in patients treated with RTB101 versus placebo in the phase 2b and phase 3 trials

RNA was isolated from whole blood obtained from patients at baseline and after 16 weeks of study drug treatment and the expression of 20 different ISGs were measured by quantitative PCR. The graphs show the change in expression of each gene from baseline to week 16 in the placebo group (black) and in the RTB101 10 mg once daily group (blue) for both the phase 2b and phase 3 trials. The number and percentage of ISGs upregulated or not upregulated from baseline to week 16 in each treatment group as assessed by ddCt are shown along with associated p values (Fisher's exact test). ddCT=delta delta cycle threshold. ISG=interferon-induced antiviral genes.