Table 2.
Effects of HXQYF against oxidative stress in NAFLD rats.
| Groups | Dose (mg·kg−1) | SOD (U/mL) | GSH (μmol/g prot) | CAT (U/mg prot) | MDA (nmol/mg prot) | HO-1 (U/L) |
|---|---|---|---|---|---|---|
| Normal | — | 88.00 ± 7.92 | 25.11 ± 4.92 | 192.04 ± 61.53 | 17.66 ± 6.73 | 38.77 ± 2.99 |
| HFD | — | 72.03 ± 8.90## | 17.72 ± 6.58## | 151.32 ± 24.22# | 26.06 ± 5.26## | 43.19 ± 1.54## |
| HXQYF | 22.5 | 79.85 ± 8.87∗ | 19.06 ± 2.69 | 176.39 ± 32.23∗ | 13.73 ± 4.05∗∗ | 42.73 ± 1.24 |
| 45 | 83.18 ± 7.35∗∗ | 22.23 ± 3.95∗ | 216.60 ± 44.79∗∗ | 12.79 ± 2.43∗∗ | 44.24 ± 3.53 | |
| 90 | 80.99 ± 11.13∗ | 24.53 ± 4.63∗∗ | 228.27 ± 43.80∗∗ | 16.30 ± 6.32∗∗ | 46.09 ± 3.23∗ | |
| ESS | 136.8 | 71.28 ± 10.62 | 20.52 ± 2.82 | 240.84 ± 32.11∗∗ | 15.18 ± 4.30∗∗ | 42.79 ± 2.66 |
The NAFLD rats were administered with the HXQYF (22.5, 45, 90 mg/kg). ESS was adopted as a positive control for comparison. After 18 weeks of treatment, superoxide dismutase (SOD), glutathione (GSH), catalase (CAT), monochrome display adapter (MDA), and Heme oxygenase-1 (HO-1) were detected. Values given are in means ± SD, with n = 10. #P < 0.05 and ##P < 0.01 versus normal. ∗P < 0.05 and ∗∗P < 0.01 versus HFD. Statistically significant differences were determined using one-way ANOVA followed by Dunnett's multiple comparisons test or post hoc analysis.