Figure 6.

Example application: selected area illumination of C. elegans. Adapted from ref. 12. (a) Frames from Supplementary Video 2 of ref. 12 demonstrating direct muscle control of a paralyzed animal using patterned light. (b) Sequential frames from Supplementary Video 3 of ref. 12 showing a bar of light passing over the animal from posterior to anterior as the animal is freely crawling. Initially the animal is traveling forward, but when the light reaches the anterior mechanosensory neurons expressing ChR2 (middle frame), the animal quickly reverses direction. (c) Sequential frames from Supplementary Video 8 of ref. 12 demonstrating the multi-spectral dynamic capacity of the illumination system. The animal is illuminated with blue light in the region of the anterior mechanosensory neuron which express ChR2 thus eliciting a reversal. The animal is subsequently illuminated with green light in the region of the command interneurons which express the hyperpolarizing MAC thus halting the reversal. Scale bar is 250 μm.