Table 1.
Top IPA Pathways Deregulated in HBs Expressing WT-NFE2L2 vs L30P/R34P
| Name of IPA pathway | Δ90+YAPS127A +L30P/R34P vs Δ90+YAPS127A Z-score | Name of IPA pathway | Δ90+YAPS127A +WT-NFE2L2 vs Δ90+YAPS127A Z-score | Name of IPA pathway | Δ90+YAPS127A +L30P/R34P vs Δ90+YAPS127A +WT-NFE2L2 Z-score |
|---|---|---|---|---|---|
| NRF2-mediated oxidative stress responsea | 3.888 | Oxidative phosphorylation | –4.359 | Fcγ receptor-mediated phagocytosis in macrophages and monocytes | 3.71 |
| tRNA charging | 3.771 | EIF2 signaling | –3.128 | NF-κB signaling | 3.266 |
| Leukocyte extravasation signaling | 3.43 | Sirtuin signaling pathway | 2.985 | Leukocyte extravasation signaling | 3.157 |
| Glutathione-mediated detoxificationa | 3.317 | NRF2-mediated oxidative stress responsea | 2.828 | IL-8 signaling | 3 |
| Role of pattern recognition receptors in recognition of bacteria and viruses | 3 | Superpathway of cholesterol biosynthesis | –3 | ||
| Ephrin receptor signaling | 3 | Role of NFAT in regulation of the immune response | 2.858 | ||
| RAN signaling | 3 | Reelin signaling in neurons | 2.84 | ||
| Apelin endothelial signaling pathway | 2.985 | LXR/RXR activation | –2.828 | ||
| Fcγ receptor-mediated phagocytosis in macrophages and monocytes | 2.982 | fMLP signaling in neutrophils | 2.673 | ||
| Opioid signaling pathway | 2.92 | Fc epsilon RI signaling | 2.668 | ||
| fMLP signaling in neutrophils | 2.828 | NRF2-mediated oxidative stress responsea | 2.558 | ||
| Glutathione redox reactions Ia | 2.828 | Apelin endothelial signaling pathway | 2.53 | ||
| TREM1 signaling | 2.53 | ||||
| ERK5 signaling | 2.53 | ||||
| Role of pattern recognition receptors in recognition of bacteria and viruses | 2.496 | ||||
| NER pathway | 2.449 | ||||
| Glutathione redox reactions Ia | 2.449 |
a
Indicates redox-regulated pathway.