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. 2020 Nov 27;35(5):1500–1505. doi: 10.1038/s41375-020-01093-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic representation of four patients sequenced at diagnosis and at relapse highlighting their clinical path and treatment. Meaning of the color is described in the legend. CHOEP chemotherapy with cyclophosphamide, doxorubicin, etoposide, vincristine and prednisone, CHOP chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone, ICE chemotherapy combination that includes ifosfamide, carboplatin and etoposide, bretux: brentuximab vedotin, GDP gemcitabine, dexamethasone, and cisplatin, GD gemcitabine and docetaxel, FU follow up. b Changes in mutational burden during tumor progression. The percentage of variant allele frequency (VAF%) for each gene is plotted at diagnosis and at relapse. The names of genes involved are reported under each plot. c 7-year PFS in systemic ALCL patients according to TP53 status; red: TP53 mutated (mut) patients; blue: TP53 wild-type (wt) patients. P values and hazard ratios (HR) shown were determined by Cox proportional hazards. d Schematic representation of p53 domains and the variants detected.