Table 1.

Substitutions at T474 and C481.

Substitutions at T474							Substitutions at C481
Single substitution	Alanine	Asparagine	Isoleucine	Proline	Serine		Serine	Threonine
	(A)	(N)	(I)	(P)	(S)		(S)	(T)
	GCT	AAT	ATT	CCT	TCT
Two or three substitutions	Fenilalanine	Glutamic acid	Glutamine	Leucine	Methionine	Valine	AGC	ACC
	(F)	(E)	(Q)	(L)	(M)	(V)
	TTC	GAA	CAG	CTG	ATG	GTG