Fig. 4. Kaplan–Meier estimate of TFS for all patients who entered the TFR phase.

TFS was defined as the time from the date of start of TFR to the date of the earliest occurrence of the following events up to the end of TFR phase: loss of MMR, death due to any cause, progression to AP/BC and re-initiation of treatment due to any cause in the study. AP/BC, accelerated phase/blast phase; MMR, major molecular response; TFR, treatment-free remission; TFS, treatment-free survival.