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. 2021 Feb 4;35(5):1405–1417. doi: 10.1038/s41375-021-01146-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Serial replating of in vitro MN1-transformed Kmt2a SET^−/− and Kmt2a SET^wt CMP. Colony numbers (left) and cell numbers (right) per 500 cells plated in duplicate. Error bars represent mean ± SEM of three biological replicates over two independent experiments. ns = non-significant, unpaired double-sided t-test. B Survival of in vitro MN1-transformed Kmt2a SET^−/− (n = 13) and Kmt2a SET^wt (n = 7) CMP recipients. Two independent experiments. p = ns, Log rank (Mantel–Cox) test. C Leukemia burden at the time of sacrifice as measured by percentage of GFP⁺ cells in the bone marrow (left), spleen weights (middle) and total white blood cell count (WBC, right). Error bars represent mean ± SEM for n = 7 Kmt2a SET^wt, n = 11 Kmt2a SET^−/−. p = ns, unpaired double-sided t-test.