Table 1.
The interacted epigenetic function of mammalian METTL protein family.
| METTLs | Function |
|---|---|
| METTL1 | tRNA, mRNA, and miRNA 7-methylguanosine (m7G) methyltransferase [114, 115] |
| METTL2 | tRNA 3-methylcytidine (m3C) methyltransferase [116] |
| METTL3 | mRNA 6-methyladenosine (m6A) methyltransferase[17] |
| METTL4 |
DNA 6-methyladenosine (6 mA) methyltransferase [117] snRNA N6 2′-O-dimethyladenosine (m6Am) methyltransferase [118] |
| METTL5 | 18S rRNA m6A methyltransferase [119] |
| METTL6 | tRNA m3C methyltransferase [116] |
| METTL8 | mRNA m3C methyltransferase [116] |
| METTL10 | Nonhistone lysine methyltransferase [120] |
| METTL11A | Histone lysine methyltransferase [121] |
| METTL11B | Proteins N-terminal mono-methytransferase [122] |
| METTL12 | Mitochondrial protein (citrate synthase) lysine methyltransferase [123] |
| METTL13 | Protein (eEF1A) lysine methyltransferase [124] |
| METTL14 | mRNA m6A methyltransferase [17, 18] |
| METTL15 | Mitochondrial 12S rRNA N4-methylcytidine (m4C) methyltransferase [125] |
| METTL16 | snRNA, lncRNA and pre-mRNA m6A methyltransferase [24, 25] |
| METTL17 | Mitochondrial 12S rRNA m4C and 5-methylcytidine (m5C) methyltransferase [126] |
| METTL20 | Mitochondrial lysine methyltransferase [127] |
| METTL21B | Nonhistone lysine methyltransferase [128] |
| METTL21C | Nonhistone lysine methyltransferase [129, 130] |
| METTL21D | Nonhistone lysine methyltransferase [131] |
| METTL22 | Nonhistone lysine methyltransferase [132] |
| METTL23 | Histone arginine methyltransferase (H3R17me2a) [133] |