Table 2.

The interacted epigenetic function of mammalian AlkB proteins.

Enzymes	Function
ALKBH1	DNA 6 mA demethylase [134]
	tRNA N1-methyladenosine (m1A) demethylase [136]
	Mitochondrial DNA 3-methylcytidine (3mC) and RNA m3C demethylase [137]
	Mitochondrial tRNA m5C demethylase [138]
ALKBH2	DNA 3mC or 1 mA demethylase [139]
	DNA and N4-ethenocytosine dioxygenase [140]
	DNA N3-ethylthymidine decarboxymethylase [141]
ALKBH2/3	DNA m5C and m3C demethylase [142]
ALKBH3	tRNA m1A and m3C demethylase [143]
ALKBH5	RNA m6A demethylase [30]
ALKBH8	tRNA 5-methoxycarbonylmethyluridine (mcm5U) methyltransferase [144]
ALKBH9 (FTO)	RNA m6A demethylase [29]
(FTO)	DNA 6 mA demethylase [145]
	Single-stranded DNA 3-methylthymine and single-stranded RNA 3-methyluracil demethylase [34]