Fig. 16.

(a) Schematic illustration of MoS₂/HSA-DOX nanocapsules targeting a cancer cell surface receptor (gp60) and their transcytosis into the cytoplasm. After irradiation, MoS₂ generates heat, and free DOX is released, achieving synergistic photothermal-chemotherapeutic efficacy. Reprinted with permission from Ref. [328]. Copyright 2018, Advanced Functional Materials. (b) Relative viabilities of KB cells after various treatments indicated. In this experiment, KB cells were incubated with MoS₂-PEG, MoS₂-PEG-FA, free DOX, MoS₂-PEG/DOX and MoS₂-PEG-FA/DOX for 1 h, and then irradiated with the 808-nm laser at different power densities for 5 min or kept dark as controls. Afterwards cells were washed with PBS, placed into fresh cell medium, re-incubated for additional 24 h before the MTT assay. Error bars were based on four parallel samples. (c) Scheme of combination therapy based on intratumorally injected MoS₂-PEG/DOX. (d) IR thermal images of 4T1 tumor-bearing mice recorded by an IR camera. The doses of DOX and MoS₂-PEG were 5 mg/kg and 3.4 mg/kg, respectively, in this experiment. Laser irradiation was conduced by using 808-nm NIR laser at the power density of 0.56 W/cm² for 20 min on the tumors. (e) Temperature change of tumors monitored by the IR thermal camera in different groups during laser. (f) Tumor volume growth curves of different groups of mice after various treatments (5 mice for each group). Reprinted with permission from Ref. [68]. Copyright 2014, Advanced Materials.