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. 2021 Apr 27;6(11):4209–4242. doi: 10.1016/j.bioactmat.2021.04.021

Fig. 4.

Fig. 4

(a) The fabrication of AuE/SC/FA for CTC capture. (b) Schematic model of HeLa cell binding with FA and repelling NC on a negatively charged AuE/SC/FA electrode surface. (c) The corresponding impedance curves. SC: Semiconductor; AuE: gold electrode; BSA: albumin from bovine serum; CTC: circulating tumor cells; FA: folic acid; NC: normal cells with low folic receptor expression. (d) Relative impedance at 10 Hz with time for AuE/MoS2/FA electrodes scanned while being immersed in HeLa cell with different concentrations in PBS. The grey solid lines indicate fittings using exponential association. (e) Calibration plots of relative impedance at 10 min for determining HeLa cells at AuE/MoS2/FA electrodes while changing the concentration of HeLa cell in PBS. (f) Relative impedance at 10 min at AuE/MoS2/FA electrodes for PBS, 10% FBS solution, MC3T3-E1 cell suspension, HeLa cell suspension and the mixture of all, indicating a good selectivity of AuE/MoS2/FA electrodes. (g) Relative impedance at 10 min at AuE/MoS2/FA electrodes for HeLa, MCF-7, MG-63 and SMMC-7721 cancer cell suspensions. Three replicates were performed. Reprinted with permission from Ref. [111]. Copyright 2019, Biosensors & Bioelectronics.