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. 2021 Apr;10(4):1368–1373. doi: 10.21037/gs-20-666

Table 2. Univariate and multivariate analyses of risk factors on CLNM in PTC patients.

Variables Number of patients CLNM
OR (95% CI) P value
Univariate analyses
   Age (years) 0.951 (0.930, 0.972) <0.001
   Gender (male vs. female) 107 vs. 299 1.672 (1.070, 2.613) 0.024
   Number of tumors (multiple vs. single) 120 vs. 286 1.200 (0.778, 1.852) 0.409
   Location of tumors (bilateral vs. unilateral) 75 vs. 331 1.647 (0.994, 2.727) 0.053
   T stage (III and II vs. I) 15 vs. 391 1.026 (0.358, 2.940) 0.962
   Capsule invasion (presence vs. absence) 44 vs. 362 0.683 (0.364, 1.280) 0.234
   NLR 3.474 (2.489, 4.848) <0.001
   PLR 1.018 (1.012, 1.024) <0.001
   LMR 0.941 (0.830, 1.068) 0.348
   SII 1.006 (1.004, 1.007) <0.001
Multivariate analyses
   Age (years) 0.924 (0.909, 0.940) <0.001
   Gender (male vs. female) 1.781 (1.060, 2.993) 0.029
   Location of tumors (bilateral vs. unilateral) 2.229 (1.228, 4.046) 0.008
   NLR 0.066
   PLR 0.310
   SII 1.005 (1.004, 1.006) <0.001

CLNM, central lymph node metastasis; PTC, papillary thyroid carcinoma; OR, odds ratio; CI, confidence interval; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; LMR, lymphocyte-to-monocyte ratio; SII, systemic immune-inflammation index.