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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Cancer Discov. 2020 Dec 14;11(5):1158–1175. doi: 10.1158/2159-8290.CD-20-0735

Figure 1: Mutations of SWI/SNF subunit genes are associated with thyroid tumor progression.

Figure 1:

(A) Oncoprint of SWI/SNF subunit mutations in human thyroid cancers. The color- coded bars in the top row represent the data study source for each sample. Tissues from the MSK clinical cohort and from Landa et al. (10) were sequenced by MSK-IMPACT. TCGA genotyping was by WES (9). (B) Frequency of SWI/SNF mutations in human papillary (PTC), poorly-differentiated (PDTC), and anaplastic thyroid cancer (ATC). (C) Clonality of SWI/SNF mutations in PTC vs PDTC/ATC. (D) Frequency of SWI/SNF mutations in different cancer types. Unlike renal and rhabdoid cancers that predominantly harbor a distinct SWI/SNF subunit mutation, thyroid (ATC) and some other cancers have mutations in diverse SWI/SNF subunits.