. Author manuscript; available in PMC: 2021 Jun 1.

Published in final edited form as: Neurotox Res. 2021 Jan 5;39(3):924–948. doi: 10.1007/s12640-020-00320-y

Table 1.

Selected studies and their results used in our meta-analyses of neurodegenerative disease and brain tumors

Study	Location	Population	Design	Type	RE	CI_L		CI_U	Cases	Exposure level	Weight^a

Amyotrophic lateral sclerosis (N = 9)
Fang et al. (2009)	USA	NEMC and BWH	CC	OR	3.0	0.7		12.9	4	> 60,000 h weighted	6.04
Peters et al. (2017)	Sweden	National Patient Register	CC	OR	1.22	0.95		1.57	123	> 0.013 mg/m³	19.22
Pinkerton et al. (2013)	USA	Garment workers	Cohort	SMR	0.94	0.19		2.75	3	> 10-year duration	6.94
Roberts et al. (2016)	USA	National Longitudinal Mortality Study	Cohort	HR	4.43	1.16		16.85	2	High intensity/probability	6.93
Seals et al. (2017)	Denmark	Danish National Patient Register	CC	rr	1.3	1.1		1.5	266	> 0.28 ppm	29.28
Weisskopf et al. (2009)	USA	ACSCPSII	Cohort	rr	4.1	2.2		7.1	13	> 10-year duration	31.58
Chiò et al. (1991) ^b	Italy	Textile workers	CC	OR	1.2	0.44^c		2.61^c	6	Ever based on job title	N/A^b
Deapen and Henderson (1986) ^b	USA	Plastics manufacturing	CC	OR	3.7	1		20.5	11	Ever based on job title	N/A^b
Gunnarsson et al. (1991)^b	Sweden	Male textile workers	CC	OR	0.1	0.3		0.7	1	Ever based on job title	N/A^b
		Male carpenter, woodworker	CC	OR	1.0	0.6		1.5	55	Ever based on job title	N/A^b
		Female textile workers	CC	OR	0.4	0.1		1.6	3	Ever based on job title	N/A^b
Parkinson’s disease (N = 6)
Chaturvedi et al. (1995)	Canada	Hobby exposure plastic resins	CC	OR	8.79	2.43		25.89	9	Ever based on hobby	0.9
Li et al. (2009)	Sweden	Male textile workers	Coh	SIR	1.03	0.61		1.63	18	Three censuses (job title)^c	5.1
		Male woodworkers	Coh	SIR	1.29	1.08		1.54	126	Three censuses (job title)^c	39.5
		Female textile workers	Coh	SIR	1.03	0.87		1.21	146	Ever based on job title	45.7
		Female woodworkers	Coh	SIR	0.66	0.30		1.26	9	Ever based on job title	2.4
Nee et al. (1991)	USA	Plastic monomers, additives worker	CC	OR	5.25	2.79^d		8.98^d	13	Ever based on job title	3.6
Hertzman et al. (1990)	Canada	Planer mills workers	CC	OR	4.11	0.91		18.5	8	Ever based on job title	0.5
Vanacore et al. (2005)	Europe	Wood and furniture worker	CC	OR	0.43	0.04		5.17	1	Ever based on job title	0.7
		Textile and clothing worker	CC	OR	2.19	0.56		8.52	7	Ever based on job title	N/A
Tanner et al. (1989)	China	O/R textile manufacture	CC	OR	1.90	0.79		4.67	unk	Ever based on O/R	1.6
		O/R lumber	CC	OR	0.87	0.13		2.19	unk	Ever based on O/R	N/A^b
		O/R plastic	CC	OR	1.62	0.61		4.31	unk	Ever based on O/R	N/A^b
		O/R paper mills	CC	OR	1.08	0.17		6.76	unk	Ever based on O/R	N/A^b
Multiple sclerosis (N = 3)
Li et al. (2008)	Sweden	Male textile workers	Coh	SIR	0.31	0.00		1.80	1	Three censuses	56.0
		Female textile workers	Coh	SIR	1.34	0.75		2.21	15	Three censuses	16.6
		Male woodworkers	Coh	SIR	0.88	0.51		1.41	17	Three censuses	18.7
Dubrow and Gute (1988)	USA	Male textile workers	Coh	PMR	1.83	0.67^c		3.98^c	6	Ever based on job title	6.1
Zorzon et al. (2003)	Italy	O/R formalin	CC	OR	0.5	0.1		1.5	4	Ever based on job title	2.6
		Woodworkers	CC	OR	1.9	0.6		6.5	8	Ever based on job title	N/A^b
Alzheimer’s disease (N = 1)
Tyas et al. (2001)	Canada	Liquid plastics and rubbers workers	Cohort	RR	1.01	0.12	8.38		1	Ever based on job title	N/A^b
		Glues, adhesives workers	Cohort	RR	1.41	0.49	4.05		5	Ever based on job title	N/A^b
Brain tumor: professional workers (N = 5)
Hall et al. (1991)	UK	Pathologists	Cohort	SMR	2.18	0.80	4.75		6	Ever	10.87
Hauptmann et al. (2009)	USA	Embalmers	CC	OR	1.7	0.5	5.3		12	Peak ≥ 9.3 ppm	8.38
Levine et al. (1984)	Canada	Undertakers	Cohort	SMR	1.15	0.24	3.51		3	Ever	7.25
Stroup et al. (1986)	USA	Anatomists	Cohort	SMR	3.9	1.0	9.9		9	Gross anatomists	8.64
Wang et al. (1989)	China	Anatomists	Cohort	SMR	8.27	1.00	29.86		2	Ever	5.34
Brain tumor: industrial workers (N = 7)
Andjelkovich et al. (1995)	USA	Iron foundry workers	Cohort	SMR	0.62	0.07	2.23		2	Ever	5.20
Beane Freeman et al. (2013)	USA	Industrial plant workers	Cohort	SMR	0.87	0.49	1.56		20	Peak ≥ 4.0 ppm	14.05
Coggon et al. (2014)	UK	Chemical factory workers	CC	SMR	0.56	0.24	1.11		8	> 2.0 ppm	12.10
Fondelli et al. (2007)	Italy	Library restoration workers	Cohort	SMR	10.03	1.22	36.24		2	Ever	5.35
Jiang et al. (1990)	China	Resin factory workers	Cohort	SMR	3.9	0.05	21.7		1	Ever	2.10
Meyers et al. (2013)	USA	Garment plant workers	Cohort	SMR	1.72	0.86	3.08		11	Duration 10+ years	13.43
Wong and Gibson (1983)	USA	Formaldehyde plant workers	Cohort	SMR	2.13	0.43	6.23		3	Hired before 1961	7.28

ACSCPII American Cancer Society Cancer Prevention Study II, BWH Brigham and Women’s Hospital, CC case-control, CIL lower 95% confidence interval, CIU upper 95% confidence interval, CS cross-sectional, hr hour, N/A not applicable, NEMC New England Medical Center, OR odds ratio, O/R occupational or residential exposure, RR relative risk, rr rate ratio, SIR standardized incidence ratios, SMR standardized mortality ratio, unk unknown.

Weight given to each study in the random effects model

Evaluated in sensitivity analyses only

Data for multiple censuses only reported for men

Calculated by us