Table 5.
Chemical gene and pathway association data from the Comparative Toxicogenomics Database (CTD), related with formaldehyde exposure, were compared with curated gene-disease associations for AD, ALS, brain tumor, MS, PD, and oNDD
| Name | NDD |
MS | BT | Total |
|||
|---|---|---|---|---|---|---|---|
| oNDD | AD | ALS | PD | ||||
| Genes | |||||||
 Superoxide dismutase 2 (SOD2) |
✓ | ✓ | ✓ | ✓ | ✓ | 5 | |
 Tumor necrosis factor (TNF) |
✓ | ✓ | ✓ | ✓ | 4 | ||
 Superoxide dismutase 1 (SOD1) |
✓ | ✓ | ✓ | 3 | |||
 Heme Oxygenase 1 (HMOX1) |
✓ | ✓ | ✓ | 3 | |||
 Insulin Like Growth Factor 1 Receptor (IGF1R) |
✓ | ✓ | ✓ | 3 | |||
 Microtubule Associated Protein Tau (MAPT) |
✓ | ✓ | ✓ | 3 | |||
 Interleukin 1 Beta (IL1B) |
✓ | ✓ | ✓ | 3 | |||
| Pathways | |||||||
 Folate Metabolism |
✓ | ✓ | ✓ | ✓ | ✓ | ✓ | 6 |
 Photodynamic therapy-induced AP-1 survival signaling. |
✓ | ✓ | ✓ | ✓ | ✓ | 5 | |
 Vitamin B12 Metabolism |
✓ | ✓ | ✓ | ✓ | ✓ | 5 | |
 Photodynamic therapy-induced NF-kB survival signaling |
✓ | ✓ | ✓ | ✓ | 4 | ||
 Amyotrophic lateral sclerosis (ALS) |
✓ | ✓ | ✓ | ✓ | 4 | ||
 Selenium Micronutrient Network |
✓ | ✓ | ✓ | ✓ | 4 | ||
 Chromosomal and microsatellite instability in colorectal cancer |
✓ | ✓ | ✓ | ✓ | 4 | ||
 Oncostatin M Signaling Pathway |
✓ | ✓ | ✓ | 3 | |||
 Copper homeostasis |
✓ | ✓ | ✓ | 3 | |||
 Oxidative Stress |
✓ | ✓ | ✓ | 3 | |||
 Viral Acute Myocarditis |
✓ | ✓ | ✓ | 3 | |||
 Lung fibrosis |
✓ | ✓ | ✓ | 3 | |||
 Overview of nanoparticle effects |
✓ | ✓ | ✓ | 3 | |||
 Allograft Rejection |
✓ | ✓ | ✓ | 3 | |||