Mice with subcutaneous 22Rv1 xenografts were treated for 3 weeks with the specified doses of vehicle controls, enzalutamide and/or NLG207, and euthanized at the completion of treatment. Average tumor volume measurements collected are plotted during the course of the study (A). Tumors, harvested following 3 weeks of treatment, were compared, as shown via photograph with one tumor per group (B), average tumor volume (C) and average tumor weight (D) at time of harvest; statistical comparisons to vehicle control above each treatment group are denoted: * - p<0.05. Daily average body weight measurements collected are summarized over the course of the study (E).