Table 1.

Summary of mIHC quantification for matched lesions at screening and EOS

Patient	Treated	CD8+ at S (cells/mm2)	CD8+ at EOS (cells/mm2)	Fold change to CD8s	CD163+ at S (cells/mm2)	CD163+ at EOS (cells/mm2)	Ratio at S CD8/CD163	Ratio at EOS CD8/CD163	Fold change CD8:CD163	FoxP3+ at S (cells/mm2)	FoxP3+ at EOS (cells/mm2)	Ratio at S CD8/FoxP3	Ratio at EOS CD8/FoxP3	Fold change CD8:FoxP3	Total PD-L1 at S (cells/mm2)	Total PD-L1 at EOS (cells/mm2)	Fold change in PD-L1
1	N	NA*	NA*		NA*	NA*				NA*	NA*				NA*	NA*
2	Y	635.31	410.79	0.65	2934.46	1542.39	0.22	0.27	1.23	74.40	104.21	8.54	3.94	0.46	5880.09	5818.34	0.99
3	Y	8.24	199.98	24.26	509.24	1102.63	0.02	0.18	11.20	8.24	28.73	1.00	6.96	6.96	1768.04	3645.96	2.06
4	N	91.74	66.00	0.72	1181.13	986.80	0.08	0.07	0.86	28.37	2.46	3.23	26.82	8.29	386.86	74.05	0.19
6	Y	97.57	458.59	4.7	1429.45	1018.55	0.07	0.45	6.60	62.04	142.56	1.57	3.22	2.05	2578.75	753.61	0.29
7	Y	50.77	78.90	1.55	2339.25	1236.81	0.02	0.06	2.94	56.91	44.63	0.89	1.77	1.98	5.01	139.03	27.73
8	N	159.44	277.12	1.74	1736.01	4983.88	0.09	0.06	0.61	158.59	77.30	1.01	3.59	3.57	6.80	295.57	43.48
10	N	78.94	24.96	0.32	504.38	3163.62	0.16	0.01	0.05	12.52	27.46	6.30	0.91	0.14	4258.22	6.39	0.001
11	Y	46.10	2444.31	53.02	2729.52	1792.39	0.02	1.36	80.74	2.46	406.59	18.74	6.01	0.32	281.36	2051.24	7.29
12	N	0.00	1626.32	>1626.32	2310.30	4750.41	NA	0.34	>0.34	2.52	351.85	NA	4.62	>4.62	6869.22	668.08	0.10

^*Slides from patient 1 did not contain enough tissue to complete the analysis