. Author manuscript; available in PMC: 2022 Jun 1.

Published in final edited form as: Hum Genet. 2021 Jan 16;140(6):865–877. doi: 10.1007/s00439-020-02250-3

Table 2.

Associations of Crohn’s disease diagnosis and height with polygenic risk scores for Crohn’s disease risk and height in the Mount Sinai Crohn’s and Colitis Registry.

Observed Trait/Disease	Adjustment		Effect size for PRS	p-value
Observed Trait/Disease	PRS	Other covariates	Effect size for PRS	p-value
			Beta, cm
Height	PRS-CD	-	−1.57 (0.56)	5.00E-03
Height	PRS-CD	CD	−1.28 (0.62)	3.87E-02
Height	PRS-height	-	3.67 (0.61)	4.28E-09
Height	PRS-height	CD	3.54 (0.62)	1.89E-08
			OR (95%CI)
CD	PRS-CD	-	4.69 (3.31–6.65)	4.01E-18
CD	PRS-CD	Height	4.62 (3.26–6.56)	9.68E-18
CD	PRS-height	-	0.62 (0.46–0.82)	1.00E-03
CD	PRS-height	Height	0.65 (0.48–0.88)	5.00E-03

PRS, polygenic risk score; PRS-CD PRS for Crohn’s Disease (CD); PRS-height, PRS for body height, both computed at the genome-wide association studies’ p-value threshold of p<1E-3. OR, odds ratio; 95%CI, 95% confidence interval. Beta and OR represent changes per interquartile increase in PRS.