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. Author manuscript; available in PMC: 2021 Nov 1.
Published in final edited form as: Clin Cancer Res. 2021 Feb 23;27(9):2636–2647. doi: 10.1158/1078-0432.CCR-20-4226

Figure 2. Marker genes and biological processes for pan-CAF subtypes.

Figure 2.

(A) UMAP (left) depicting subtypes and heatmap (right) depicting marker genes associated with pan-CAF subtypes. Pan-myCAF, myofibroblast-like CAFs; pan-dCAF, desmoplastic CAFs; pan-iCAF and pan-iCAF-2, inflammatory-like CAFs; pan-nCAF, normal myofibroblasts; pan-pCAF, proliferating CAFs. (B) Fraction of CAF subtypes in individual cancer types. (C) Dot plot showing expression of marker genes for pan-CAF subtypes. (D) Enriched gene sets for pan-CAF subtypes. (E) UMAP depicting cell cycle states of pan-CAF subtypes. (F) Heatmap of expression of genes associated with selected functions. (G) Heatmap of expression of genes encoding cell-surface proteins.