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. Author manuscript; available in PMC: 2022 May 4.
Published in final edited form as: Cell Metab. 2021 Apr 21;33(5):905–922.e6. doi: 10.1016/j.cmet.2021.03.025

Figure 7. Increased Ile intake attenuates the beneficial effects of LP on obesity and is associated with higher BMI in human.

Figure 7.

(A) Experimental scheme. (B) Average food consumption during the first month on the indicated diets normalized by body weight. (C–F) Body weight (C), fat mass (D), lean mass (E), and glucose tolerance (F) of mice consuming WD Ctrl AA, WD Low AA, WD Low AA + Ile, and WD Low AA + BCAA diets. (B-F) n=6 cages of 2 animals each/group (B) or n=11–12/group (C-F); *p<0.05, Sidak’s test post ANOVA; each group compared to the WD Ctrl AA and WD Low AA groups. (G) Heatmap of the metabolic effects of each diet. (H) Association between body mass index (BMI) and percent of total protein from Ile from the SHOW study (n=788, shaded area represents 95% CI). (I) Graphic summary of the study. Data represented as mean ± SEM.