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. Author manuscript; available in PMC: 2022 May 3.
Published in final edited form as: Dev Cell. 2021 Apr 21;56(9):1221–1233. doi: 10.1016/j.devcel.2021.03.033

Figure 3. Multiple mitochondrial compartments control apoptosis via diverse mechanisms.

Figure 3.

Mitochondrial compartments (OMM, IMS, IMM, and matrix) maintain organelle function and homeostasis while harboring the potential to enable, initiate, and execute apoptosis. A brief summary of each mitochondrial compartment’s activities and/or signaling pathways that directly communicate to the apoptosis machinery are indicated. Detailed descriptions are provided in the text. Abbreviations: AIF, apoptosis-inducing factor; cyt c, cytochrome c; ETC, electron transport chain; ROS, reactive oxygen species; TCA, tricarboxylic acid; VDAC, voltage-dependent anion channel.