Table 3.

Signaling capacity of some elevated metabolites in the knockout or probenecid-treated animals

Lipid	G-protein coupled receptor or nuclear receptor ligand (59, 60, 61)
Myristic acid (14:0)	✔
Pentadecanoate (15:0)	✔
Palmitic acid (16:0)	✔
Palmitoleic acid (16:1)	✔
Linoleate (18:2n6)	✔
Linolenate [alpha or gamma; (18:3n3 or 6)]	✔
Gamma-linolenic acid (18:3n6)	✔
Stearidonate (18:4n3)	✔
Nonadecanoate (19:0)	✔
Arachidate (20:0)	✔
Dihomo-linoleate (20:2n6)	✔
Eicosapentaenoate (EPA; 20:5n3)	✔
Docosatrienoate (22:3n3)	✔