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. 2021 Mar 21;296:100575. doi: 10.1016/j.jbc.2021.100575

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Tryptophan metabolism is one of the most altered pathways in both knockout mice.A, volcano plot for the Oat1 KO (n = 5) showing the tryptophan metabolites against all other measured metabolites. B, tryptophan metabolism is the second most enriched pathway for significantly elevated metabolites. C, volcano plot for the Oat3 KO (n = 3) showing the tryptophan metabolites against all other measured metabolites. D, tryptophan metabolism is the most enriched pathway for significantly elevated metabolites based on metabolon subpathway analysis.