Table 1.
Summary of known physiological characteristics of Oat1 KO and Oat3 KO mice
| Characteristic | Oat1 KO | Oat3 KO |
|---|---|---|
| Viable | ✓ | ✓ |
| Fertile | ✓ | ✓ |
| Histological abnormalities | None observed | None observed |
| Anatomic abnormalities | None observed | None observed |
| Body weight | Comparable to wildtype | Comparable to wildtype |
| Renal function | Comparable to wildtype | Comparable to wildtype |
| General metabolic parameters | Comparable to wildtype | Comparable to wildtype |
| General physiological parameters | Comparable to wildtype | Lower blood pressure |
| Lifespan | Comparable to wildtype | Comparable to wildtype |
A check mark indicates no differences from wild-type animals. General metabolic parameters include oxygen consumption, carbon dioxide production, food and water intake, and locomotor activity. General physiological parameters include body weight and plasma chemistries. Data are from (25, 26, 27, 28).