Table 2.
Drugs and toxins with altered elimination in Oat1 KO and Oat3 KO mice or reduced uptake in ex vivo or in vivo experiments with tissues from these mice
| Drug or toxin | Oat1 KO | Oat3 KO | In vivo or ex vivo | Reference |
|---|---|---|---|---|
| Antivirals | ✓ | ✓ | Ex vivo | (36) |
| Antibiotics | ✓ | ✓ | In vivo | (30) |
| Diuretics | ✓ | ✓ | In vivo | (32) |
| Fluoroquinolone antibiotics | ✓ | In vivo | (31) | |
| Mercury | ✓ | In vivo | (33) | |
| Uremic Toxins | ✓ | ✓ | In vivo | (34, 35) |
| Uric acid | ✓ | ✓ | In vivo | (25) |
A check indicates altered handling or elimination based on cited reference.