Table 3.

Glucose consumption, glucose uptake and NO inhibition of compounds 1–28 isolated from E.subumbrans roots and twigs.

Compound	Glucose consumption (IC50, μM)	Glucose uptake (fold)	NO Inhibition (IC50, μM)	Cell viability of 3T3-L1 cells (%)	Cell viability raw 264.7 cells (%)
1	Inactive	Inactive	Inactive	54.1 ± 0.9	99.4 ± 0.6
2	Inactive	Inactive	Inactive	76.5 ± 1.1	56.1 ± 2.4
3	Inactive	Inactive	Inactive	84.3 ± 1.6	13.2 ± 0.7
4	Inactive	Inactive	Inactive	94.4 ± 0.5	97.3 ± 0.3
5	Inactive	Inactive	Inactive	34.2 ± 0.9	98.6 ± 1.6
6	Inactive	Inactive	Inactive	65.5 ± 1.2	3.7 ± 0.2
7	Inactive	Inactive	Inactive	85.2 ± 1.8	3.1 ± 0.9
8	Inactive	Inactive	Inactive	40.5 ± 0.9	2.9 ± 0.6
9	Inactive	Inactive	Inactive	78.3 ± 0.7	3.3 ± 0.2
10	Inactive	Inactive	Inactive	64.2 ± 0.3	3.0 ± 0.1
11	Inactive	Inactive	Inactive	43.9 ± 0.9	18.9 ± 0.3
12	Inactive	Inactive	Inactive	56.5 ± 1.3	95.1 ± 0.7
13	Inactive	Inactive	Inactive	36.9 ± 0.8	3.4 ± 0.1
14	Inactive	Inactive	Inactive	43.1 ± 0.4	2.8 ± 0.1
15	Inactive	Inactive	Inactive	77.3 ± 1.4	92.9 ± 0.8
16	Inactive	Inactive	96.2 ± 1.61	39.7 ± 1.9	98.4 ± 0.5
17	Inactive	Inactive	Inactive	43.6 ± 1.1	97.7 ± 0.6
18	Inactive	Inactive	Inactive	41.6 ± 1.8	5.7 ± 1.1
19	Inactive	Inactive	Inactive	79.6 ± 1.8	3.8 ± 0.1
20	Inactive	Inactive	Inactive	84.7 ± 0.9	93.7 ± 0.7
21	Inactive	Inactive	Inactive	74.5 ± 1.4	81.3 ± 0.5
22	Inactive	Inactive	Inactive	80.8 ± 1.2	3.67 ± 0.9
23	Inactive	Inactive	Inactive	26.9 ± 0.9	12.1 ± 1.1
24	Inactive	Inactive	Inactive	39.7 ± 0.7	3.7 ± 0.1
25	Inactive	Inactive	Inactive	62.4 ± 1.4	3.4 ± 0.2
26	33.4 ± 0.34	1.3 ± 0.21	Inactive	97.5 ± 0.3	21.6 ± 1.5
27	29.1 ± 0.86	2.8 ± 0.47	52.5 ± 0.56	98.2 ± 1.7	97.9 ± 1.2
28	Inactive	Inactive	Inactive	40.6 ± 1.1	97.1 ± 0.2
Metformin	47.2 ± 1.17	3.7 ± 0.96	NT	96.1 ± 0.9	99.4 ± 0.6
Aminoguanidine	NT	NT	22.4 ± 0.78	NT	97.9 ± 0.8

Inactive at >100 μM.