Table 3.
Glucose and Insulin Relative Responses for Phases 2 and 3.
| Comparison∗ | All (n=25) | Outliers excluded | Means∗∗ | All (n=25) | Outliers excluded | |
|---|---|---|---|---|---|---|
| Phase 2 Glucose | 100%×Dex35F15/Dex35 | 108.2±6.3 | 105.1±5.71# | 100%×DF/D [100; 80,120] | 99.7±4.7 (89.9, 109.5)ˆ | 99.7±4.70 (89.9, 109.5)# |
| 100%×Dex50F15/Dex50 | 96.9±6.4ˆ | 94.1±5.91# | ||||
| 100%×Dex35/Dex50 | 79.5±5.0ˆ | 77.0±4.61# | 100%×35/50 [80.6; 64.5,96.7] | 82.0±3.3 (75.1, 88.8)ˆ | 78.7±2.62 (73.2, 84.2)# | |
| 100%×Dex35F15/Dex50F15 | 87.7±4.1ˆ | 85.9±3.91# | ||||
| Phase 2 Insulin | 100%×Dex35F15/Dex35 | 133.4±13.9 | 118.5±10.02 | 100%×DF/D [100; 77.2,122.8] | 108.0±6.3 (94.9, 121.1)ˆ | 100.6±4.02 (92.3, 108.9)# |
| 100%×Dex50F15/Dex50 | 102.9±8.9ˆ | 96.3±6.21# | ||||
| 100%×Dex35/Dex50 | 68.1±5.6ˆ | 68.1±5.60# | 100%×35/50 [70, 54,86] | 72.6±3.6 (65.1, 80.0)ˆ | 70.6±3.11 (64.1, 77.0)# | |
| 100%×Dex35F15/Dex50F15 | 83.5±6.4 | 80.5±5.91 | ||||
| Phase 3 Glucose | 100%×WB35F15/WB35 | 107.1±8.0 | 99.0±6.22# | 100%×WBF/WB [100; 80,120] | 105.7±5.6 (94.1, 117.3)ˆ | 105.7±5.60 (94.1, 117.3)# |
| 100%×WB50F15/WB50 | 111.9±8.7 | 105.8±6.51# | ||||
| 100%×WB35/WB50 | 79.8±5.8ˆ | 77.4±5.51# | 100%×35/50 [79.1; 63.3,94.9] | 74.9±3.7 (67.2, 82.6)ˆ | 74.7±3.22 (68.1, 81.3)# | |
| 100%×WB35F15/WB50F15 | 74.6±4.9ˆ | 71.3±3.71# | ||||
| Phase 3 Insulin | 100%×WB35F15/WB35 | 116.2±11.7 | 104.6±9.22 | 100%×WBF/WB [100; 77.2,122.8] | 111.9±6.6 (98.3, 125.5) | 107.3±5.01 (97.0, 117.5)# |
| 100%×WB50F15/WB50 | 120.5±11.9 | 110.9±7.21 | ||||
| 100%×WB35/WB50 | 70.0±5.9ˆ | 63.7±4.32# | 100%×35/50 [67.6; 52.2,83.0] | 64.4±2.9 (58.4, 70.4)ˆ | 64.2±2.52 (59.1, 69.3)# | |
| 100%×WB35F15/WB50F15 | 65.1±5.5ˆ | 62.3±4.91# |
Results are means±SEM for n=25 subjects. 95% confidence intervals (95%CI) shown in (brackets).
∗ iAUC elicited by one test-meal expressed as a % of that after another; test-meal abbreviations: Dex35F15 = 35g dextrose+15g FOSS; Dex35 = 35g dextrose; Dex50F15 = 50g dextrose+15g FOSS, Dex50 = 50g dextrose.
∗∗ iAUC elicited by the mean of 2 test-meals expressed as a % of the mean for 2 test-meals as follows: DF/D=(Dex35F15+Dex50F15)/(Dex35+Dex50), 35/50=(Dex35D+Dex35)/(Dex50F15+Dex50) or (WB35F15+WB35)/(WB50F15+WB50), WBF/WB=(WB35F15+WB50F15)/(WB35+WB50). Expected mean and 95%CI shown in [brackets].
ˆ equivalent to expected (95%CI of n=25 values lie within the equivalence margins).
# 95%CI of values after excluding outliers are within the equivalence margins.
0,1,2 Number of outliers excluded.