Table 1.
The most differentially regulated pathways in Rpl11 haploinsufficient erythroid precursor cells.
| Comparison | Pathway term | FDR P value |
|---|---|---|
| Most upregulated in cluster A cells | Oxidative phosphorylation | 1.68E-07 |
| Mitochondrial morphogenesis | 3.98E-05 | |
| Mitochondrial ribosome | 4.18E-04 | |
| Electron transport chain | 4.58E-03 | |
| Purine biosynthesis | 5.00E-05 | |
| Proteasome | 2.63E-04 | |
| Most downregulated in cluster A cells | HMGB2 pathway | 9.98E-10 |
| Chromatin binding | 2.15E-03 | |
| Kinase activity | 2.19E-02 | |
| Definitive hemopoiesis | 4.29E-03 | |
| Histone ubiquitination | 8.30E-03 | |
| Hallmark mitotic spindle | 1.61E-02 | |
| Most upregulated in cluster D cells | Oxygen binding | 5.08E-03 |
| Oxygen transport | 4.00E-03 | |
| Hemoglobin complex | 4.15E-03 | |
| GTP cyclohydrolase I activity | 1.82E-03 | |
| Hemoglobin alpha binding | 1.00E-04 | |
| Glycolysis - gluconeogenesis | 3.46E-02 | |
| Most downregulated in cluster D cells | Gata1 cluster | 7.13E-20 |
| Hallmark mitotic spindle | 1.23E-10 | |
| Aurkb pathway | 1.37E-09 | |
| E2F targets | 4.28E-08 | |
| Welch GATA1 targets | 9.56E-07 | |
| Abnormal reticulocyte morphology | 4.31E-06 |