Table 4.
Regression coefficient for change in patient reported, clinical, laboratory and ultrasound assessments in relation to change of fatigue during 1-year follow-up of patients with rheumatoid arthritis initiating biologic DMARDs.
| 1 month | 2 months | 3 months | 6 months | 12 months | |
|---|---|---|---|---|---|
| Patients global | 1.05** (0.84,1.26) | 1.04** (0.79,1.29) | 1.12** (0.86,1.39) | 0.93** (0.67,1.18) | 0.8** (0.48,1.12) |
| Joint pain VAS | 0.47* (0.17,0.76) | 0.51* (0.19,0.82) | 0.59** (0.28,0.91) | 0.36* (0.05,0.66) | 0.33 (− 0.01,0.68) |
| MHAQ | 0.54** (0.29,0.79) | 0.25 (− 0.03,0.52) | 0.47* (0.16,0.77) | 0.68** (0.4,0.95) | 0.56* (0.23,0.89) |
| SF36 Mental Health | − 0.77** (− 1, − 0.54) | − 0.78** (− 1.04, − 0.53) | − 0.7** (− 0.98, − 0.43) | − 0.53** (− 0.79, − 0.27) | − 0.35* (− 0.66, − 0.04) |
| Pain Catastrophizing | 0.62** (0.38,0.86) | 0.63** (0.36,0.89) | 0.79** (0.52,1.06) | 0.66** (0.4,0.92) | 0.43* (0.1,0.76) |
| Tender joint count | 0.36* (0.11,0.61) | 0.34* (0.06,0.62) | 0.4* (0.12,0.69) | 0.35* (0.08,0.62) | 0.16 (− 0.18,0.49) |
| Examiner’s global VAS | 0.61** (0.37,0.85) | 0.64** (0.37,0.91) | 0.52** (0.24,0.8) | 0.62** (0.36,0.88) | − 0.11 (− 0.45,0.22) |
| Calprotectin | 0.45** (0.2,0.7) | 0.52** (0.25,0.79) | 0.37* (0.09,0.66) | 0.47** (0.21,0.74) | 0.58** (0.29,0.87) |
| CRP | 0.12 (− 0.13,0.38) | 0.34* (0.07,0.61) | 0.4* (0.12,0.69) | 0.23 (− 0.04,0.5) | 0.4* (0.08,0.72) |
| Swollen joint count | 0.33* (0.08,0.58) | 0.26 (− 0.01,0.54) | 0.22 (− 0.07,0.51) | 0.36* (0.1,0.63) | 0.45* (0.13,0.77) |
| Grey Scale | 0.33* (0.08,0.58) | 0.35* (0.07,0.62) | 0.55** (0.28,0.83) | 0.43* (0.17,0.69) | 0.29 (− 0.01,0.6) |
| Power Doppler | 0.27* (0.01,0.52) | 0.35* (0.08,0.62) | 0.49** (0.21,0.77) | 0.43* (0.17,0.69) | 0.41* (0.11,0.72) |
Table gives regression coefficient for (standardized) change in patient reported, clinical, laboratory and ultrasound assessments (independent variable) and change in fatigue (dependent variable). All values are adjusted for baseline fatigue, with 95% CI in parentheses
VAS visual analogue scale, MHAQ modified health assessment questionnaire, SF36 Mental Health short form 36 Mental Health scale score, DAS28 disease activity score with 28 joints and erythrocyte sedimentation rate, CDAI clinical disease activity score, SDAI simple disease activity score, CRP C-reactive protein, GS grey scale ultrasound, PD power Doppler ultrasound
*p < 0.05, **p < 0.001