Table 1.
Phenotype of Rubicon-deficient mouse models.
| Rubicon model | Stress | Phenotype | Ref. |
|---|---|---|---|
| Systemic knockout | Aging | Activates basal autophagy, reduces age-associated features | 48 |
| LPS injection | Protects against lethality and contributes to maintaining cardiac stroke volume | 45 | |
| Neuronal knockout (Nestin-cre) | α-Syn fibrils | Suppresses expansion of α-synuclein pathology | 48 |
| Hepatocyte knockout (Alb-cre) | HFD (high fat diet) | Ameliorates liver steatosis | 50 |
| Cardiomyocyte knockout (Myh6-cre) | I/R | Attenuates I/R injury and reduces autosis | 8 |
| Adipocyte knockout (Adipoq-cre) | Aging | Promotes metabolic disorder due to excess autophagy | 49 |