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. 2021 May 7;6:174. doi: 10.1038/s41392-021-00550-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Effects of AAIT on peripheral blood CD4+/CD8+ T-cell counts and HIV RNA in severely immunosuppressed AIDS patients. a The trend of CD4⁺ T-cell counts in severely immunosuppressed AIDS patients. b Changes in CD4⁺ T-cell counts in each of the 12 severely immunosuppressed AIDS patients. c The trend of CD8⁺ T-cell counts in severely immunosuppressed AIDS patients. d Changes in CD8⁺ T-cell counts in each of the 12 severely immunosuppressed AIDS patients. e The trend of CD4/CD8 ratio in severely immunosuppressed AIDS patients. f Changes in CD4/CD8 ratio in each of the 12 severely immunosuppressed AIDS patients. g The change of HIV RNA in patients receiving ART before AAIT (n = 7). h The change of HIV RNA in patients receiving AAIT before ART (n = 5). For patient 05-Z, the AAIT was 20 days before ART. For patient 08-D, the AAIT was 8 days before ART. For patient 10-L, the AAIT was 7 days before ART. For the other two patients, the AAIT was 2 days before ART. The arrows represent the time of ART start