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. 2021 May 6;12(5):450. doi: 10.1038/s41419-021-03724-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Percentage bar plot of cell type composition in healthy and psoriatic skin, y-axis represented the percent of total cell number of that cell type. Red color represented psoriatic skin and blue color represented healthy control skin. Significant changes (FDR < 0.01) were labeled as ** on the top. B Dot plot of cell number distribution of each cell type in each healthy and psoriasis donor. Dot size represented the cell number percent of that donor (x-axis) in that cell type (y-axis). Color indicated the cell types. C Dot plot of the significant existence of each susceptibility gene loci (x-axis) in each cell type (y-axis). Color indicated each cell type. D Bar plot of the raw counted of four selected HLA genes in cell type EpD_Foli. Red color represented psoriatic skin and blue color represents healthy control skin. Y-axis represents the mean value of the expression raw counts. ***, FDR p < 0.001; *, p < 0.05. E, F GO-bioprocess enrichment plot of all psoriasis upregulated genes in cell type EpD_Granular/spinous (E) and Mes_Fibro (F). Red frame highlighted the significant enriched GO terms and the terminally enriched GO-bioprocess were enlarged at the bottom of each plot.