Fig. 5. Schematic view of the immune regulation from local resident epidermal cells and mesenchymal cells to DCs.

Resident cells including basal cells, hair follicle-like cells, mesenchymal cells potentialize local inflammation by evoking MHC complex genes in psoriatic condition, and these cells can trigger dendritic cells for the inflammatory cascade through remodeling ECM and secreting cytokines such as LIF, IL-6, IL-17B, IL-36, and CD58.