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. 2021 May 6;11:9677. doi: 10.1038/s41598-021-89000-1

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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The effect of 11,12-EET and 19,20-EDP on PA-induced inflammatory mediator expression by Müller cells. Human Müller cells were treated with PA (250 μM) for 24 h. 11,12-EET (0.5 μM) or 19,20-EDP (0.5 μM) was added during the final 3 h of treatment. After 24 h, total RNA was isolated and expression was assayed by qRT-PCR. (a) TNFα (b) IL1β, and (c) IL6 expression was significantly decreased by both epoxygenated fatty acids. (d) IL8 expression was reduced but statistical significance was not achieved. Results depicted are representative of three separate experiments. Data are displayed as mean ± SD (n = 3 or 4 for each experiment).