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. 2021 May 6;11:9677. doi: 10.1038/s41598-021-89000-1

Figure 3.

Figure 3

The effect of sEH inhibitor GSK2256294 on PA-induced inflammatory mediator expression by Müller cells. Human Müller cells were treated with PA (250 μM) or PA plus 0.1 nM, 1.0 nM or 10 nM GSK2256294 (sEH inhibitor). After 24 h, total RNA was isolated, and expression was analyzed by qRT-PCR. (a) TNFα, (b) IL1β, (c) IL6, and (d) IL8 expression was significantly decreased by the addition of the sEH inhibitor at each of the concentrations tested. Results depicted are representative of three separate experiments. Data are displayed as mean ± SD (n = 3 or 4 for each experiment).