Table 3.
A summary of the in vitro antimicrobial susceptibility and resistance of the causative microorganisms of infectious keratitis.
| Year | Authors | Study period | Region | No. of cases | Antibiotic susceptibility (%)a | ||
|---|---|---|---|---|---|---|---|
| CEP | AMG | FQ | |||||
| UK and Europe | |||||||
| 2017 | Tan et al. [9] | 2004–2015 | UK | 4229 | 86 (P); 61 (N); | 88 (P); 97 (N) | 83 (P); 91 (N) |
| 2019 | Tavassoli et al. [24] | 2006–2017 | UK | 2614 | – | 100 (P); 97.0-100 (N) | 91-100 (P); 97-100 (N) |
| 2020 | Ting et al. [8] | 2007–2019 | UK | 1333 | 100 (P); 81 (N) | 95 (P); 98-99 (N) | 90-100 (P); 98-100 (N) |
| North America | |||||||
| 2017 | Tam et al. [25] | 2000–2015 | Canada | 2330 | – | 96 (P) | 96 (P) |
| 2018 | Peng et al. [26] | 1996–2015 | US | 2203 | – | 50-100 (N) | 85-100 (P); 80-100 (N) |
| 2020 | Asbell et al. [28] | 2009–2018 | US | 6091 | – | 97 (MSSA); 62 (MRSA); 94 (MS-CoNS); 71 (MR-CoNS); 97 (N) | 89-90 (MSSA); 26-29 (MRSA); 88-89 (MS-CoNS); 43-49 (MR-CoNS); 93-100 (N) |
| South America | |||||||
| 2013 | Vola et al. [150] | 2000–2009 | Brazil | 566 | – | 93 (MSSA); 70 (MRSA) | 96 (MSSA); 62 (MRSA) |
| 2015 | Hernandez-Camarena et al. [31] | 2002–2011 | Mexico | 1638 | 18-90 (P); 10-92 (N) | 42-80 (P); 69-98 (N) | 54-100 (P); 87-100 (N) |
| Asia | |||||||
| 2013 | Kaliamurthy et al. [35] | 2005–2012 | India | 2170 | – | 31-95 (P); 90-93 (N) | 70.4-98 (P); 74-90 (N) |
| 2016 | Hsiao et al. [38] | 2003–2012 | Taiwan | 2012 | – | 85-88 (N) | 89 (P); 94 (N) |
| 2019 | Acharya et al. [40] | 2015–2017 | India | 1169 | – | 73 (P); 89 (N) | 69 (P); 69 (N) |
| 2019 | Lin et al. [41] | 2010–2018 | China | 7229 | 84-91 (P); 68-75 (N) | – | 63-75 (P); 46-75 (N) |
| Africa and Middle East | |||||||
| 2016 | Politis et al. [42] | 2002–2014 | Jerusalem | 943 | – | 92-94 (P) | 97-100% (P) |
| Australasia | |||||||
| 2019 | Cabrera-Aguas et al. [43] | 2012–2016 | Australia | 1084 | – | 86-97 (P); 100 (N) | 86-95 (P); 99 (N) |
| 2019 | Green et al. [21] | 2005–2015 | Australia | 3182 | – | 92 (P); 96 (N) | 94 (P); 99 (N) |
MSSA Methicillin-sensitive Staphylococcus aureus, MRSA Methicillin-resistant S. aureus, MS-CoNS Methicillin-sensitive coagulase negative staphylococci, MR-CoNS Methicillin-resistant coagulase negative staphylococci.
aAntibiotic susceptibility is reported for Gram-positive bacteria (P) and Gram-negative bacteria (N) against three common classes of antibiotics, namely cephalosporin (CEP), aminoglycoside (AMG) and fluoroquinolone (FQ).