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. 2021 May 6;11:9735. doi: 10.1038/s41598-021-89122-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of the impact of the application of Block I and Block II anodal M1 tDCS over early and the chronic phase of neuropathic pain post-nerve injury (SNI), respectively, on cold allodynia and motor function. (A,B) Partial, significant reversal of allodynia to cold, shown in form of latency of nociceptive responses to 5° temperature, by repetition of anodal M1 tDCS in chronic phase post-SNI (Block II), but not by the first 5-day cycle of M1 tDCS over the early phase post-SNI (Block I) in comparison with the respective sham treatment group on. (C,D) Early and short-lasting enhancement of locomotion parameters by anodal M1 tDCS (Block II). n = 7 mice for the sham treatment group and n = 6 mice for repetitive M1 tDCS group; ANOVA for repeated measures was performed, followed by Sidak’s test for multiple comparisons; *indicates p < 0.05 as compared to the corresponding sham group, # indicates p < 0.05 as compared to the pre-stimulation value within each group. ϕ indicates p < 0.05 as compared to the basal value within each group Data are represented as mean + /− S.E.M.