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. 2021 May 6;11:9644. doi: 10.1038/s41598-021-88959-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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TGFBI KO mice show higher vessel density in adipose tissue compared with WT mice. (a) Genotyping was performed using PCR. The amplification targeted exon 3 of the TGFBI gene. (b) Plasma TGFBI concentrations in 20-week-old WT and KO mice (n = 3/group). (c) Representative H&E staining of iWAT sections from 20-week-old male WT and KO mice (n = 5/group). The red arrow indicates a large vessel (≥ 10 µm in diameter). Scale bars represent 200 μm. (d) The vessels were counted in sections from three mice, and expressed as mean number. (e,f) Representative images of CD31 immunohistofluorescence staining of iWAT from 20-week-old male WT and KO mice (n = 5/group). Scale bars represent 50 μm. (f) Quantification of area percentage of CD31 staining using ImageJ software. Data are presented as the mean ± S.E.M. *p < 0.05 versus WT.