Table 1.
Mouse tumor models used to study the effects of caspase-2 deficiency on tumourigenesis.
| Mouse model | Tumor | Effect of caspase-2 deficiency | Refs |
|---|---|---|---|
| Eµ-Myc | Lymphoma | Heterozygous and homozygous caspase-2 deficiency accelerated lymphoma development in Eµ-Myc mice. | 55,64,92 |
| Atm−/− | Thymoma | Accelerated thymic tumor development in Atm−/− mice. | 63 |
| MMTV/c-neu | Mammary tumor | Homozygous caspase-2 deficiency accelerated mammary tumor formation in MMTV/c-neu mice. | 65 |
| TH-MYCN | Neuroblastoma | Heterozygous and homozygous caspase-2 deficiency delayed neuroblastoma development in TH-MYCN mice. | 96 |
| Kras | Lung tumor | Homozygous caspase-2 deficiency accelerated proliferation and progression of lung tumors driven by Kras. | 93 |
| Diethylnitrosamine | Hepatocellular carcinoma | Accelerated hepatocellular carcinoma development. | 94 |
| Suppression of hepatocellular carcinoma development. | 95 |