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. 2021 May 6;11:9666. doi: 10.1038/s41598-021-88508-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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TNF-α production in CD4+ and CD8+ T cells upon stimulation with progesterone metabolites. Progesterone (Prog), 5α-dihydroprogesterone (5α-DHP), 6α-hydroxypregnanolone (6α-OH-Pregn) and dexamethasone (Dexa), were added at a concentration of 10⁻³ M to the PBMCs obtained from 3 different female donors for 24 h. 6 h after first steroid hormone contact, PBMCs were activated with PMA/Ionomycin. TNF-α positive CD4+ and CD8+ T cells were counted by FACS analysis. The y-axis shows the % of CD4+ (a) and CD8+ (b) T cells positively staining for TNF-α. * p < 0.05, ** p < 0.01, *** p < 0.0001, ns = not significant.